MODY in Latin America

Maturity Onset Diabetes of the Young (MODY) is an early onset monogenic diabetes. Despite MODY patients presenting with features and treatment requirements different from other types of diabetes, it is commonly misdiagnosed as type 1 or type 2 diabetes. MODY is an autosomal dominant inherited disorder caused by β-cell dysfunction, characterised by a vast range of different phenotypes due to genetic heterogeneity. In fact, 14 genes have been associated with MODY phenotypes which reinforces the importance of genetic testing.
Heterozygous pathogenic variants in the GCK, HNF1A, HNF4A, and HNF1B genes are the four most common causes of this type of diabetes.